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Fnord
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24 Sep 2021, 8:54 am

NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism.

Exposure to acetaminophen in the womb may increase a child’s risk for attention deficit/hyperactivity disorder and autism spectrum disorder, suggests a study funded by the National Institutes of Health and the Agency for Health Care Research and Quality.  The study was conducted by Xiaobing Wang, M.D., of the Johns Hopkins University Bloomberg School of Public Health, Baltimore, and colleagues.  It appears in JAMA Psychiatry.

Researchers analyzed data from the Boston Birth Cohort, a long-term study of factors influencing pregnancy and child development.  They collected umbilical cord blood from 996 births and measured the amount of acetaminophen and two of its byproducts in each sample.  By the time the children were an average of 8.9 years, 25.8% had been diagnosed with ADHD only, 6.6% with ASD only and 4.2% with ADHD and ASD.  The researchers classified the amount of acetaminophen and its byproducts in the samples into thirds, from lowest to highest.  Compared to the lowest third, the middle third of exposure was associated with about 2.26 times the risk for ADHD.  The highest third of exposure was associated with 2.86 times the risk. Similarly, ASD risk was higher for those in the middle third (2.14 times) and highest third (3.62 times).

The authors conclude that their results support earlier studies linking acetaminophen exposure in the womb with ADHD and ASD and underscore the need for additional research.

The U.S. Food and Drug Administration urges careful consideration before using any pain-relieving medication during pregnancy.



Source:
 This National Institutes of Health Article 


Caveat: This is a report on a statistics-based study, which found correlation between acetaminophen and the incidence of ASDs and ADD/ADHD.  While no causal connection was proven beyond a reasonable doubt, the correlation is strong enough to warrant further study and research.



DW_a_mom
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24 Sep 2021, 8:25 pm

Sigh. More reasons for me to worry I messed with my own kids. We have obvious genetic links in our family history, but what about the increase in severity between generations? I used to get a lot of headaches back then and acetaminophen is what doctors recommended.

OK, turning off the worry button. It does no good.


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funeralxempire
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24 Sep 2021, 9:02 pm

DW_a_mom wrote:
Sigh. More reasons for me to worry I messed with my own kids. We have obvious genetic links in our family history, but what about the increase in severity between generations? I used to get a lot of headaches back then and acetaminophen is what doctors recommended.

OK, turning off the worry button. It does no good.


It's too late to change anything and no one knew.


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Dox47
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24 Sep 2021, 9:06 pm

DW_a_mom wrote:
Sigh. More reasons for me to worry I messed with my own kids. We have obvious genetic links in our family history, but what about the increase in severity between generations? I used to get a lot of headaches back then and acetaminophen is what doctors recommended.

OK, turning off the worry button. It does no good.


Hmm, kind of similar here, both headaches and autism run in my family, so I'm sure I was both genetically predisposed, but also my mother likely took plenty of headache pills when pregnant with me. I'd echo that it's not really worth worrying about.


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